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Metabolic Research Studies have examined the combination’s downstream metabolic effects in pre-clinical models — including its influence on glucose metabolism, lipid oxidation, insulin sensitivity, and protein synthesis — reflecting the broad metabolic role of the GH/IGF-1 axis and research interest in how dual-pathway GH stimulation affects systemic metabolic regulation
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Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Cheng and Ristow, 2013), steroid hormone biosynthesis, removal of ammonia, integration of metabolic and signaling pathways for cell death and autophagy (Hammerman et al., 2004